CLINICAL TRIALS ON ALZHEIMER’S DISEASE (CTAD)
BARCELONA, SPAIN, NOVEMBER 5-7, 2015

Clinical trials devote considerable effort and resources to rater training and quality assurance of ADAS-Cog endpoints. To examine the efficacy of these efforts in improving ADAS­Cog reliability, we evaluated the impact of central data review on ADAS­-Cog test-­retest reliability. Results indicate that central data review improved ADAS-Cog ICCs and substantially reduced the rate of missing data.

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